The first game of defending the title was won! Zverev lost only 3 games and easily passed the championship, successfully entering the top 32 at Rome

In the early morning of May 10, the second round of the ATP1000 Rome Masters continued. The 2nd seed of the tournament and defending champion Zverev played, and his opponent was the 60th Argentinian Karaberi. In this game, Zverev easily won in two straight sets and successfully entered the third round of men's singles. In the first set, Zverev broke the opponent's serve as soon as he came up, and then held the serve and took a 2-0 lead. In the fourth game, Zverev lost the serve and the game was tied 2-2. After that, Zverev broke the serve twice in the 5th and 7th games, and won the first set 6-2 after four consecutive games.

Zverev broke and defended at the beginning of the second set, gaining a 2-0 advantage. In the fifth game, Zverev broke again and expanded his lead 4-1. In the 7th game, Zverev broke the serve with 4 points in a row, winning the second set 6-1.

Finally, in a game that took 1 hour and 06 minutes, Zverev easily defeated Karabery, who ranked 60th in the world, 6-1, and advanced to the top 32 with 7 consecutive victories in the Rome Masters. In the next third round, Zverev will face the net against the qualifying player Gobas who broke through the qualifying round, who unexpectedly eliminated the No. 27 seed Shapovalov.

This victory against Karabery was the 64th Clay Masters in Zverev's personal career. He tied Wawrinka and tied for the second most winning games in the active Clay Masters, second only to Djokovic, who won 113 wins.